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Effect of inhaled corticosteroids on airway resistance measured by the interrupter technique (R int)in preschool children with wheeze and cough)

Start date: January 1999Planned end date: January 2001
Estimated cost: £105,745


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Research objectives

It has been shown that lung function testing using Rint is feasible in young children, and is abnormally high in children previously wheezy. An objective test for the monitoring of the effect of therapy is thus now available for the pre-school group. Atopic and non-atopic children who wheeze and cough almost certainly have different mechanisms for their symptoms. In the first group inflammation similar to atopic older asthmatics is likely, as is benefit from corticosteroids. Children with small airways are more likely to have recurrent chest symptoms and be represented in the non-atopic group. It is hypothesised that the latter are less likely to benefit from corticosteroids. To help target treatment appropriately, this study will measure the effect of fluticasone in atopic and non-atopic children with recurrent symptoms using change in R int as the principal outcome. This project will compare symptom response to change in R int.


For further information contact

Dr Sheila McKenzie
Consultant Paediatrician and Honorary Senior Lecturer
Department of Respiratory Medicine
Queen Elizabeth Children's Service
2nd Floor, Fielden House
Royal London Hospital
Whitechapel
London, E1 1BB
e-mail: mckenzie@rhtch.demon.co.uk


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Last updated 21 May 1999
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